WEE1-IN-5 |
| رقم الكتالوجGC65994 |
WEE1-IN-5 هو مثبط WEE1 قوي بقيمة IC50 تبلغ 0.8 نانومتر. WEE1-IN-5 يثبط phospho-CDC2. WEE1-IN-5 يلغي نقطة فحص G2 ، مما يزيد من الحساسية لعوامل تلف الحمض النووي في الخلايا السرطانية. يمكن استخدام WEE1-IN-5 للبحث عن مضادات السرطان.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2243882-74-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer[1].
WEE1-IN-5 exhibits an EC50 of 188 nM in pCDC2 and an IC50 shift for CYP3A4/5[1].
WEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUCint 1324 h.ng/mL and bioavailability of 35% in SD rats[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *