MAPK Signaling

(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).

7-oxo Staurosporine is an antibiotic originally isolated from S.

8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.

Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2.

AR420626 is an oral active and selective agonist of free fatty acid receptor 3 (FFAR3) with an EC 50 value of 2.2µM.

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM).

C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells.

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes.

CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM.

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively).

The Survival of Motor Neurons (SMN) protein participates in RNA splicing.

Guanosine 3',5'-cyclic monophosphate (cyclic GMP or cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases.

Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines.

Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties.

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM).

Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit.

Guanylyl Imidodiphosphate (lithium salt), a stable GTP analog, is a potent activator of adenylate cyclase.

Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. HA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator.

A resorcylic acid lactone polyketide

L-858,051 is a water-soluble analog of forskolin, a cell-permeant activator of adenylate cyclase.

L-Sulforaphene is a natural isothiocyanate with anti-inflammatory, anticancer, and antioxidant effects.

LY2584702 (tosylate) is a potent, highly selective adenosine triphosphate (ATP) competitive inhibitor against p70 S6 kinase, a downstream component of the phosphatidylinositol-3-kinase signalling pathway with an IC 50 value of 0.004μM.

Methylcarbamyl PAF C-8 is the C-8 analog of Methylcarbamyl PAF C-16.

MK2 Inhibitor III (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM.