MAPK Signaling

p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM).

PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase.

PKA Inhibitor (5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM.

PQ-10 is a potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM).

Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.

Rp-8-CPT-Cyclic AMP (sodium salt), a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II.

Sorafenib N-oxide is an active metabolite of sorafenib, an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases.

Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.

Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.

Tpl2 Kinase Inhibitor (TKI) is a cell-permeable naphthyridine compound that acts as a potent reversible and ATP-competitive inhibitor of Tpl2 kinase.

A MEK inhibitor

A neuropeptide with diverse biological activities

A TNIK inhibitor

For screening of a variety of kinase inhibitors

2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate is a cAMP analog that can be covalently coupled to acetylcholinesterase.

A dual ERK1 and ERK5 inhibitor

An internal standard for the quantification of carvedilol

An internal standard for the quantification of cilostazol

An internal standard for the quantification of dabrafenib

A neuropeptide with diverse biological activities

An inhibitor of MAP4K2 and TAK1

A PDE4B inhibitor

A synthetic peptide inhibitor of PKA

A linearized form of cyclic di-AMP