Stem Cell

Induces differentiation of mouse embryonic stem cells (ESCs) into cardiomyocytes

3-Deazaneplanocin A (DZNep) hydrochloride is an adenosine analogue and is a competitive S-adenosylhomocysteine hydrolase inhibitor with a Ki of 50 pM in cell-free tests.

Salinomycin sodium salt is a macrocyclic polyether ionophore antibiotic produced by the fermentation of Streptomyces albus .

PKF118-310 (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity.

Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development.

Temiverine hydrochloride is a synthesized drug that is expected to have anticholinergic action.

An inhibitor of Wnt signaling

PF-05274857 (hydrochloride) is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-05274857 (hydrochloride) has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.

MMP-8 Inhibitor I is a potent matrix metalloproteinase-8 (MMP-8) inhibitor with low oral bioavailability.

JS-K is a nitric oxide (NO) donor that reacts with glutathione to generate NO at physiological pH.

An inhibitor of GSK3β

ETC-159 is a potent, orally available PORCN inhibitor.

iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription.

A potent and selective Wnt/β-catenin inhibitor

NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21 nM.

Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM.

SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases.

M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.

WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM.

YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.

Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC50 of 9 nM.

Heparan Sulfate is a complex polyanionic polysaccharide, regulates important developmental processes in invertebrates and vertebrates.

tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.

Adavivint (SM04690) (SM04690; Lorecivivint) is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells.