M2912 (Synonyms: MSC2504877) |
| Catalog No.GC25603 |
M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1460286-21-8
Sample solution is provided at 25 µL, 10mM.
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M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.
[1] Buchstaller HP, et al. J Med Chem. 2021 Jul 22;64(14):10371-10392.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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