1-Methylnicotinamide (chloride) (Synonyms: N1-Methylnicotinamide chloride, Nicotinamide methochloride, Trigonellamide chloride) |
| رقم الكتالوجGC42000 |
1-ميثيل نيكوتيناميد (كلوريد) (1-ميثيل نيكوتيناميد كلوريد) هو مستقلب داخلي المنشأ.
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Cas No.: 1005-24-9
Sample solution is provided at 25 µL, 10mM.
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Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase . It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
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