10(S),17(S)-DiHDHA (Synonyms: 10(S),17(S)-DiHDoHE, PDX, Protectin DX) |
| رقم الكتالوجGC40971 |
10 (S) ، 17 (S) -DiHDHA (المعروف أيضًا باسم Neuroprotectin D1 عند إنتاجه في الأنسجة العصبية) هو حمض دهني ثنائي هيدروكسي مشتق من DHA يعرض أنشطة وقائية قوية ومضادة للالتهابات
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Cas No.: 871826-47-0
Sample solution is provided at 25 µL, 10mM.
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Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stereochemistry of the C-10 hydroxyl and the double bond configuration at the 13 and 15 positions. 10(S),17(S)-DiHDHA blocks neutrophil infiltration in murine peritonitis by 20-25% at a dose of 1 ng/mouse. It also inhibits platelet activation by both impairing thromboxane (TX) synthesis and TX receptor activation.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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