Phillygenin (Phillygenol) (Synonyms: Epipinoresinol methyl ether, (+)-Phillygenin) |
رقم الكتالوجGC30080
One-Click Copy Product Info
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Phillygenin (Phillygenol) (Phillygenol) هو مكون نشط من فورسيثيا مع العديد من الخصائص الطبية ، مثل مضادات الأكسدة ، وتقليل نسبة الدهون في الدم ، وتثبيط أكسدة البروتين الدهني منخفض الكثافة.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 487-39-8
Sample solution is provided at 25 µL, 10mM.
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Phillygenin is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation.In vitro : 1) Phillygenin shows a greater inhibition on mouse B16 melanoma cells potential than vincristine.2) phillygenin had notable scavenging activity against DPPH, ABTS radicals, as well as potent reducing power in FRAP assay.In vivo: The reference for rat is 5.6 mg/m l ( i.v).
[1]. Ye LH et al. Determination of phillygenin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Eur J Drug Metab Pharmacokinet, 2013 Sep, 38(3):201-7. [2]. Song W et al. Interaction between phillygenin and human serum albumin based on spectroscopic and molecular docking. Spectrochim Acta A Mol Biomol Spectrosc, 2012 Jan, 85(1):120-6.
| Cas No. | 487-39-8 | SDF | |
| المرادفات | Epipinoresinol methyl ether, (+)-Phillygenin | ||
| Canonical SMILES | OC1=CC=C([C@H]2OC[C@@]3([H])[C@]2([H])CO[C@H]3C4=CC=C(OC)C(OC)=C4)C=C1OC | ||
| Formula | C21H24O6 | M.Wt | 372.41 |
| الذوبان | DMSO : 50 mg/mL (134.26 mM);Water : < 0.1 mg/mL (insoluble) | Storage | Store at -20°C, protect from light, stored under nitrogen |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6852 mL | 13.4261 mL | 26.8521 mL |
| 5 mM | 537 μL | 2.6852 mL | 5.3704 mL |
| 10 mM | 268.5 μL | 1.3426 mL | 2.6852 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)