17-chlorophenyl trinor Prostaglandin F2α ethyl amide (Synonyms: Chlorophenyl Bimatoprost, 17chlorophenyl trinor PGF2α ethyl amide) |
| رقم الكتالوجGC41954 |
Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. In addition, PGF2α can activate the PGE2 receptor EP1, albeit at higher concentrations, evoking inflammatory effects. Replacement of the ω-terminal three carbons with a phenyl group, producing 17-phenyl PGF2α, gives a ligand with both greater affinity for FP and diminished affinity for EP1. Compounds based on this structure are effective in lowering intraocular pressure, reducing ocular hypertension and limiting the progression of glaucoma. 17-phenyl PGF2α ethyl amide (Bimatoprost) is a prodrug which, after entering the cornea, is hydrolyzed to give the corresponding free acid. 17-chlorophenyl trinor Prostaglandin F2α ethyl amide has a chlorine atom substituted into the meta position of the phenyl group of 17-phenyl PGF2α ethyl amide. The meta substitution of a halogen (fluorine) at this site on the free acid increases its affinity for the FP receptor and greatly decreases its affinity for the EP1 receptor.
| Cas No. | SDF | ||
| المرادفات | Chlorophenyl Bimatoprost, 17chlorophenyl trinor PGF2α ethyl amide | ||
| Canonical SMILES | O[C@@H]1[C@H](C/C=C\CCCC(N([H])CC)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC(Cl)=C2)[C@H](O)C1 | ||
| Formula | C25H36ClNO4 | M.Wt | 450.1 |
| الذوبان | DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 0.1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.2217 mL | 11.1086 mL | 22.2173 mL |
| 5 mM | 444.3 μL | 2.2217 mL | 4.4435 mL |
| 10 mM | 222.2 μL | 1.1109 mL | 2.2217 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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