5-(N,N-Hexamethylene)-amiloride (Synonyms: HMA) |
| رقم الكتالوجGC35147 |
5- (N ، N-Hexamethylene) -amiloride (Hexamethylene amiloride) مشتق من amiloride وهو مثبط قوي لمبادل Na + / H ، مما يقلل من درجة الحموضة داخل الخلايا (pHi) ويحفز موت الخلايا المبرمج في ابيضاض الدم الخلايا
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Cas No.: 1428-95-1
Sample solution is provided at 25 µL, 10mM.
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[1][2]. Na+/H+ exchanger[1]EC50: 3.91 μM (MHV replication), 1.34 μM (HCoV229E replication)[2]
[1]. Rich IN, et al. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood. 2000 Feb 15;95(4):1427-34. [2]. Wilson L, et al. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology. 2006 Sep 30;353(2):294-306. Epub 2006 Jul 3.
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