22-(tert-Butoxy)-22-oxodocosanoic acid |
| رقم الكتالوجGC64146 |
22- (tert-Butoxy) -22-oxodocosanoic acid هو رابط ADC غير قابل للانقسام يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs)22- (tert-Butoxy) -22-oxodocosanoic acid هو أيضًا رابط PROTAC قائم على سلسلة الألكيل يمكن استخدامه في
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Cas No.: 1642333-05-8
Sample solution is provided at 25 µL, 10mM.
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22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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