4-Hydroxyestradiol (Synonyms: 4-Hydroxy-17β-estradiol) |
| رقم الكتالوجGC19552 |
4-هيدروكسي إستراديول (4-هيدروكسي -17β ؛ -استراديول) هو مستقلب داخلي من استراديول. 4-هيدروكسي إستراديول مادة مسرطنة ويظهر نشاط مطفر في الخلايا الظهارية للثدي. 4-Hydroxyestradiol يثبط ارتباط استراديول بمستقبلات الاستروجين بطريقة تنافسية ، مع Ki 0.48 نانومتر.
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Cas No.: 5976-61-4
Sample solution is provided at 25 µL, 10mM.
4-Hydroxyestradiol is a catechol estrogen and minor metabolite of estrogen.[1][2] 4-Hydroxyestradiol is formed from estrogen by the cytochrome P450 (CYP) isoform CYP1B1.[2] Production of 4-hydroxyestradiol is increased in microsomes prepared from human mammary adenocarcinoma and fibroadenoma microsomes compared with microsomes prepared from non-cancerous tissues.[1] 4-Hydroxyestradiol (25 mg/animal) induces renal tumor formation in male hamsters.[3]
Reference:
[1]. Liehr, J.C., and Ricci, M.J. 4-Hydroxylation of estrogens as marker of human mammary tumors. Proc. Natl. Acad. Sci. USA 93(8), 3294-3296 (1996).
[2]. Yager, J.D., and Liehr, J.G. Molecular mechanisms of estrogen carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 36, 203-232 (1996).
[3]. Liehr, J.G., Fang, W.F., Sirbasku, D.A., et al. Carcinogenicity of catechol estrogens in Syrian hamsters. J. Steroid Biochem. 24(1), 353-356 (1986).
| Cas No. | 5976-61-4 | SDF | |
| المرادفات | 4-Hydroxy-17β-estradiol | ||
| Chemical Name | (17β)-estra-1,3,5(10)-triene-3,4,17-triol | ||
| Canonical SMILES | C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C(O)=C4CC3 | ||
| Formula | C18H24O3 | M.Wt | 288.38 |
| الذوبان | DMF: 20 mg/ml,DMSO: 25 mg/ml,Ethanol: 25 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.4676 mL | 17.3382 mL | 34.6765 mL |
| 5 mM | 0.6935 mL | 3.4676 mL | 6.9353 mL |
| 10 mM | 0.3468 mL | 1.7338 mL | 3.4676 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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