5-Methoxyindole-3-acetic acid (Synonyms: 5-methoxy IAA, 5-Methoxyindoleacetic Acid, 5-MIAA) |
| رقم الكتالوجGC46078 |
5-ميثوكسي إندول -3-حمض الخليك هو مستقلب الميلاتونين
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3471-31-6
Sample solution is provided at 25 µL, 10mM.
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5-Methoxyindole-3-acetic acid (5-MIAA) is a methoxyindole that is synthesized in rat pineal gland, retina, and harderian gland.1 Following conversion to a peroxyl radical by horseradish peroxidase (HRP), 5-MIAA increases the rate of formation of thiobarbituric acid reactive substances (TBARS) in liposomes and is cytotoxic to V79 hamster cells.2,3 In vivo, 5-MIAA (100 and 200 μg/animal) prolongs the estrous cycle and increases diestrous smears, uterine weight, the number of uterine follicles, and plasma levels of 17β-estradiol in female rats.1
|1. Ocal-Irez, T., Durmus, G., Sekerkiran, Y., et al. Effect of a pineal indolamine, 5-methoxyindole-3-acetic acid, on the estrous cycle and reproductive organs of female wistar albino rats. Brain Res. 493(1), 1-7 (1989).|2. Candeias, L.P., Folkes, L.K., Porssa, M., et al. Enhancement of lipid peroxidation by indole-3-acetic acid and derivatives: Substituent effects. Free Radic. Res. 23(5), 403-418 (1995).|3. Folkes, L.K., Candeias, L.P., and Wardman, P. Toward targeted "oxidation therapy" of cancer: Peroxidase-catalysed cytotoxicity of indole-3-acetic acids. Int. J. Radiat. Oncol. Biol. Phys. 42(4), 917-920 (1998).
| Cas No. | 3471-31-6 | SDF | |
| المرادفات | 5-methoxy IAA, 5-Methoxyindoleacetic Acid, 5-MIAA | ||
| Canonical SMILES | OC(CC1=CNC2=CC=C(OC)C=C21)=O | ||
| Formula | C11H11NO3 | M.Wt | 205.2 |
| الذوبان | DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.8733 mL | 24.3665 mL | 48.7329 mL |
| 5 mM | 974.7 μL | 4.8733 mL | 9.7466 mL |
| 10 mM | 487.3 μL | 2.4366 mL | 4.8733 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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