6-Methylflavone |
| رقم الكتالوجGC30898 |
6-ميثيل فلافون منشط لمستقبلات α1β2γ2L و α1β2 GABAA
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 29976-75-8
Sample solution is provided at 25 µL, 10mM.
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6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone enhances the normal response to GABA at recombinant α1β2γ2L and α1β2 GABAA receptors (P<0.0001) at concentrations from 1 to 100 μM. 6-Methylflavone (60 μM) shifts the GABA dose-response curve to the left (n=4, F=16.38, P=0.0004), decreasing the mean EC50 at α1β2γ2L GABAA receptors by 33±5.4%[1].
[1]. Hall BJ, et al. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol. 2004 Apr 26;491(1):1-8.
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