6RK73 |
رقم الكتالوجGC39625 |
6RK73 هو مثبط تساهمي لا رجوع فيه ومثبط UCHL1 محدد مع IC50 من 0.23 ميكرومتريُظهر 6RK73 عدم وجود أي تثبيط تقريبًا لـ UCHL3 (IC50 = 236 ميكرومتر)6RK73 يمنع على وجه التحديد نشاط UCHL1 في سرطان الثدي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1895050-66-4
Sample solution is provided at 25 µL, 10mM.
6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer[1].
[1]. Liu S, et al. Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis. Clin Cancer Res. 2019 Dec 19. pii: clincanres.1373.2019.
Average Rating: 5
(Based on Reviews and 10 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *