AD 01 |
| رقم الكتالوجGC50581 |
AD 01 ، 24 ببتيد من الأحماض الأمينية من FKBPL (مثل بروتين رابط FK506) ، يمتلك نشاطًا قويًا مضادًا لتولد الأوعيةيرتبط AD 01 بمستقبل CD44 ويمنع هجرة الخلايا السرطانية بطريقة تعتمد على CD44
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Cas No.: 959961-23-0
Sample solution is provided at 25 µL, 10mM.
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FKBPL (FK506-binding protein like)-based peptide. Binds to and upregulates expression of CD44. Inhibits breast cancer stem cell (BCSC) growth. Decreases pluripotency markers and promotes differentiation of BCSCs. Also inhibits endothelial cell migration as well as tubule and microvessel formation in vitro and in vivo. Blocks tumor growth in xenograft models.
Yakkundi et al (2013) The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. PLoS One. 8 e55075 PMID:23457460 |McClements et al (2013) Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway. Clin.Cancer Res. 19 3881 PMID:23741069 |Valentine et al (2011) FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism. Clin.Cancer Res 17 1044 PMID:21364036
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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