Lenalidomide-C4-NH2 hydrochloride (Synonyms: Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride) |
| رقم الكتالوجGC60984 |
هيدروكلوريد Lenalidomide-C4-NH2 هو يجند Cereblon القائم على Lenalidomide المستخدم في توظيف بروتين CRBNيمكن توصيل هيدروكلوريد ليناليدوميد- C4-NH2 بالرابط الخاص بالبروتين بواسطة رابط لتشكيل PROTAC (المركب 24) ، الذي يحتوي على IC50s من 0.98 نانومتر و 13.7 نانومتر في تثبيط RS4 ؛ 11 و MOLM-13 نمو خطوط خلايا سرطان الدم الحاد ، على التوالى.
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Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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