Aloperine |
| رقم الكتالوجGC14314 |
Aloperine هو قلويد في نباتات الصفيراء مثل Sophora alopecuroides L ، والتي أظهرت خصائص مضادة للسرطان ومضادة للالتهابات ومضادة للفيروسات
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Cas No.: 56293-29-9
Sample solution is provided at 25 µL, 10mM.
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Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1].
Aloperine (1-20 mM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM, the IC50 values in HL-60, U937, K562, EC109, A549 and HepG2 cells are 0.04, 0.27, 0.36, 1.11, 1.18 and 1.36 mM,respectively[1].Aloperine (1-20 mM; 24 hours) induces apoptosis and decreases bcl-2 expression in HL-60 cells[1].Aloperine (20–100 mM; 18 hours) induces autophagy and formation of acidic vacuole in HL-60 cells[1].
References:
[1]. Lin Z, et al. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin Pharmacol Toxicol. 2011 May;108(5):304-9.
[2]. Yuan XY, et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Eur J Pharmacol. 2010 Mar 10;629(1-3):147-52.
| Cas No. | 56293-29-9 | SDF | |
| Chemical Name | (6R,6aR,13R,13aS)-2,3,4,6,6a,7,8,9,10,12,13,13a-dodecahydro-1H-6,13-methanodipyrido[1,2-a:3',2'-e]azocine | ||
| Canonical SMILES | [H][C@@]1([C@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C2=C3[H])C([H])([H])[C@@]3([H])[C@](C([H])([H])C([H])([H])C([H])([H])C4([H])[H])([H])N4C1([H])[H] | ||
| Formula | C15H24N2 | M.Wt | 232.36 |
| الذوبان | ≥ 9.25mg/mL in DMSO with gentle warming | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.3037 mL | 21.5183 mL | 43.0367 mL |
| 5 mM | 0.8607 mL | 4.3037 mL | 8.6073 mL |
| 10 mM | 0.4304 mL | 2.1518 mL | 4.3037 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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