Alternariol monomethyl ether (Synonyms: AME, NSC 638262) |
| رقم الكتالوجGC18437 |
يعتبر Alternariol monomethyl ether ، المعزول من جذور Anthocleista djalonensis (Loganiaceae) ، علامة تصنيفية مهمة لأنواع النباتات.
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Cas No.: 23452-05-3
Sample solution is provided at 25 µL, 10mM.
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Alternariol monomethyl ether (AME) is a mycotoxin originally isolated from A. brassicae extracts. AME is a common contaminant in cereal grains such as wheat, barley, and sorghum that is cytotoxic to bacterial (MIC = 500 μg/disc for B. mycoides in a bacterial halo assay) and mammalian cells (IC50 = 120 μM in HCT116 cells). It inhibits human topoisomerase II and bacterial gyrase at initial inhibitory concentrations of 25 and 10 μM, respectively. AME selectively inhibits monoamine oxidase A (MOA-A; Ki = 0.34 μM). AME also provokes DNA damage that induces mitochondrial permeability transition pore-mediated activation of apoptosis.
Review for Alternariol monomethyl ether
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
Review for Alternariol monomethyl ether
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