Antimycin A3 |
| رقم الكتالوجGC42819 |
Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 522-70-3
Sample solution is provided at 25 µL, 10mM.
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Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4 . Antimycin A3 binds to the Q(inner) site of mitochondrial complex III (cytochrome bc1) and inhibits mitochondrial respiration (IC50 = 38 nM in isolated rat liver mitochondria). It also inhibits ATP-citrate lyase with a Ki value of 60.1 µM, and it stimulates the production of reactive oxygen species. In molecular modeling studies, antimycin binds to a mutant form of Bcl-2 (hBcl-2δ22) and has a Kd value of 0.82 µM for binding to a recombinant mutant form of Bcl-2 (rhBcl-2δ22) in an isothermal calorimetry assay.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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