Antitrypanosomal agent 1 |
| رقم الكتالوجGC39478 |
العامل المضاد للتريبانوزوم 1 هو مثبط فعال وانتقائي للتريبانوثيون اختزال (TR) مع IC 50 من 3.3 ميكرومتر
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Cas No.: 75144-12-6
Sample solution is provided at 25 µL, 10mM.
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Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1].
[1]. Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3.
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