AZ3391 |
رقم الكتالوجGC65899
One-Click Copy Product Info
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AZ3391 مثبط قوي لـ PARP. AZ3391 هو مشتق كينوكسالين. تلعب عائلة إنزيمات PARP دورًا مهمًا في عدد من العمليات الخلوية ، مثل التكرار وإعادة التركيب وإعادة تشكيل الكروماتين وإصلاح تلف الحمض النووي. AZ3391 لديه القدرة على البحث عن الأمراض والحالات التي تحدث في أنسجة الجهاز العصبي المركزي ، مثل الدماغ والحبل الشوكي (مستخرج من براءة الاختراع WO2021260092A1 ، المركب 23).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2756333-42-1
Sample solution is provided at 25 µL, 10mM.
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AZ3391 is a potent inhibitor of PARP. AZ3391 is a quinoxaline derivative. PARP family of enzymes play an important role in a number of cellular processes, such as replication, recombination, chromatin remodeling, and DNA damage repair. AZ3391 has the potential for the research of diseases and conditions occurring in tissues in the central nervous system, such as the brain and spinal cord (extracted from patent WO2021260092A1, compound 23)[1].
| Cas No. | 2756333-42-1 | SDF | |
| Formula | C23H27FN6O2 | M.Wt | 438.5 |
| الذوبان | DMSO : 16.67 mg/mL (38.02 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2805 mL | 11.4025 mL | 22.805 mL |
| 5 mM | 456.1 μL | 2.2805 mL | 4.561 mL |
| 10 mM | 228.1 μL | 1.1403 mL | 2.2805 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)