Azido-PEG5-alcohol |
| رقم الكتالوجGC65819 |
Azido-PEG5-alcohol عبارة عن رابط PEG ADC مكون من 5 وحدات غير قابل للكسر يستخدم في تخليق اتحادات الأجسام المضادة والمخدرات (ADCs). Azido-PEG5-alcohol هو أيضًا رابط PROTAC قائم على PEG يمكن استخدامه في تخليق PROTACs.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 86770-68-5
Sample solution is provided at 25 µL, 10mM.
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Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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