Azido-PEG5-alcohol |
| Katalog-Nr.GC65819 |
Azido-PEG5-Alkohol ist ein nicht spaltbarer PEG-ADC-Linker mit 5 Einheiten, der bei der Synthese von AntikÖrper-Wirkstoff-Konjugaten (ADCs) verwendet wird. Azido-PEG5-Alkohol ist auch ein PEG-basierter PROTAC-Linker, der bei der Synthese von PROTACs verwendet werden kann.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 86770-68-5
Sample solution is provided at 25 µL, 10mM.
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Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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