Azido-PEG6-NHS ester |
| رقم الكتالوجGC61869 |
Azido-PEG6-NHS ester عبارة عن رابط PEG ADC قابل للانقسام مكون من 6 وحدات يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs)Azido-PEG6-NHS ester هو أيضًا رابط PROTAC قائم على PEG و Alkyl / ether والذي يمكن استخدامه في تخليق PROTACs
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055014-64-5
Sample solution is provided at 25 µL, 10mM.
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Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs[2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References:
[1]. Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14712-14717.
[2]. John W. Babich, et al. Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies. WO2018187631A1.
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