Benzomalvin A (Synonyms: (-)-Benzomalvin A) |
| رقم الكتالوجGC40889 |
البنزومالفين A هو مضاد قوي لمستقبلات نيوروكينين المعزولة من Penicillium sp
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Cas No.: 157047-96-6
Sample solution is provided at 25 µL, 10mM.
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Benzomalvin A is a fungal metabolite produced by Penicillium. It inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM). In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 μM, respectively).
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