BIA 10-2474 |
| رقم الكتالوجGC18174 |
BIA 10-2474 هو مثبط للأحماض الدهنية أميد هيدرولاز (FAAH) بقيم IC50 من 50 إلى 70 مجم / كجم في مناطق دماغ الفئران المختلفة
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1233855-46-3
Sample solution is provided at 25 µL, 10mM.
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BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme). It also inhibits FAAH2, α/β-hydrolase domain-containing protein 6 (ABHD6), carboxylesterase 2 (CES2), and patatin-like phospholipase domain 6 (PNPLA6) with IC50 values of 0.4, 0.081, 2, and 11 μM, respectively. BIA 10-2474 alters expression of 161 lipid species, including FAAH substrates as well as other lipid classes, in human cortical neuron cultures indicating compound promiscuity. Formulations containing BIA 10-2474 were previously investigated clinically for the management of chronic pain but use was halted due to development of significant neurotoxicity.
Review for BIA 10-2474
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
Review for BIA 10-2474
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