Bisindolylmaleimide XI (hydrochloride) (Synonyms: BIM XI, Ro 310432) |
| رقم الكتالوجGC18716 |
Bisindolylmaleimide XI (هيدروكلوريد) (Ro 32-0432) هو مثبط قوي ، انتقائي وفعال عن طريق الفم مع PKC من 9 نانومتر ، 28 نانومتر ، 31 نانومتر ، 37 نانومتر ، و 108 نانومتر لـ PKCα ، PKCβI ، PKCβII ، PKCγ ، و PKCε ، على التوالى.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 145333-02-4
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Bisindolylmaleimide XI (BIM XI) is a selective, cell-permeable protein kinase C (PKC) inhibitor that displays 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca2+-independent PKCε (IC50 = 108 nM). Inhibition of PKCα by BIM XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. BIM XI prevents T-cell activation and proliferation (with IC50s ranging from 30-150 nM) associated with chronic inflammatory responses in vivo.
Review for Bisindolylmaleimide XI (hydrochloride)
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
Review for Bisindolylmaleimide XI (hydrochloride)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *