Bisindolylmaleimide XI (hydrochloride) (Synonyms: BIM XI, Ro 310432) |
| Katalog-Nr.GC18716 |
Bisindolylmaleimid XI (Hydrochlorid) (Ro 32-0432) ist ein potenter, selektiver und oral aktiver PKC-Inhibitor mit IC50-Werten von 9 nM, 28 nM, 31 nM, 37 nM und 108 nM für PKCα, PKCβI, PKCβII, PKCγ und PKCε , beziehungsweise.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 145333-02-4
Sample solution is provided at 25 µL, 10mM.
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Bisindolylmaleimide XI (BIM XI) is a selective, cell-permeable protein kinase C (PKC) inhibitor that displays 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca2+-independent PKCε (IC50 = 108 nM). Inhibition of PKCα by BIM XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. BIM XI prevents T-cell activation and proliferation (with IC50s ranging from 30-150 nM) associated with chronic inflammatory responses in vivo.
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