Calcium channel-modulator-1 |
| رقم الكتالوجGC32616 |
معدل قناة الكالسيوم -1 هو مُعدِّل قناة الكالسيوم ؛ كتل انكماش الأبهر مع IC من 0.8 ميكرومتر
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Cas No.: 136941-70-3
Sample solution is provided at 25 µL, 10mM.
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Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC50 of 0.8 μM.
Oral administration of Calcium channel-modulator-1 (20 mg/kg) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure which was more pronounced and long-lasting than that of nifedipine[1].
[1]. Sunkel CE, et al. Synthesis of 3-[(2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl)alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators. J Med Chem. 1992 Jun 26;35(13):2407-14.
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