Carboxyamidotriazole Orotate (Synonyms: L-651582 Orotate; CAI Orotate) |
| رقم الكتالوجGC39646 |
Carboxyamidotriazole Orotate (L-651582 Orotate) هو شكل ملح orotate من Carboxyamidotriazole (CAI) ، وهو مثبط نقل الإشارة المتوفر بيولوجيًا عن طريق الفم
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Cas No.: 187739-60-2
Sample solution is provided at 25 µL, 10mM.
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Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects[1][2].
[1]. Corrado C, et al. Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis. PLoS One. 2012;7(8):e42310. [2]. Hussain MM, et al. Phase II trial of carboxyamidotriazole in patients with relapsed epithelial ovarian cancer. J Clin Oncol. 2003 Dec 1;21(23):4356-63.
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