ABT-670 |
| رقم الكتالوجGC33552 |
ABT-670 هو ناهض انتقائي متاح حيويًا عن طريق الفم لمستقبلات الدوبامين D4 ، مع EC50 من 89 نانومتر ، 160 نانومتر ، و 93 نانومتر للإنسان D4 ، النمس D4 ، والفأر D4 ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 630119-43-6
Sample solution is provided at 25 µL, 10mM.
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ABT-670 is a selective, oral bioavailable agonist of dopamine D4 receptor, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively.
ABT-670 is a selective D4 agonist, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively[1].
ABT-670 (0.1 μmol/kg) robustly induces a high (75%) incidence of erections in male rats. ABT-670 exhibits excellent oral bioavailability in rat, dog, and monkey (68%, 85%, and 91%, respectively) with comparable efficacy, safety, and tolerability[1].
[1]. Patel MV, et al. Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J Med Chem. 2006 Dec 14;49(25):7450-65.
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