Cyclo(Phe-Pro) (Synonyms: A-64863, Cyclo(phenylalanylprolyl), cFP) |
| رقم الكتالوجGC35779 |
Cyclo (Phe-Pro) (Cyclo (phenylalanylprolyl)) ، جزيء Vibrio vulnificus لاستشعار النصاب ، يثبط الجين I (RIG-I) الذي يحفزه حمض الريتينويك ، من خلال تفاعله المحدد مع RIG-I ، لتقليل IRF-3 التنشيط وإنتاج النوع الأول IFN
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14705-60-3
Sample solution is provided at 25 µL, 10mM.
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Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses[1].
[1]. Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606.
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