LP 922761 |
| رقم الكتالوجGC50391 |
LP 922761 هو مثبط بروتين -2 محول قوي وانتقائي وفعال عن طريق الفم مرتبط بالكيناز 1 (AAK1) مع IC50s من 4.8 نانومتر و 7.6 نانومتر في فحوصات الإنزيم والخلية ، على التوالي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1454808-95-7
Sample solution is provided at 25 µL, 10mM.
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Potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.
Kostich et al (2016) Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J.Pharmacol.Exp.Ther. 358 371 PMID:27411717
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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