LP 922761 |
| カタログ番号GC50391 |
LP 922761 は、酵素アッセイと細胞アッセイでそれぞれ 4.8 nM と 7.6 nM の IC50 を持つ強力で選択的な経口活性アダプター プロテイン 2 関連キナーゼ 1 (AAK1) 阻害剤です。
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Cas No.: 1454808-95-7
Sample solution is provided at 25 µL, 10mM.
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Potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.
Kostich et al (2016) Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. J.Pharmacol.Exp.Ther. 358 371 PMID:27411717
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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