ZLDI-8 |
| رقم الكتالوجGC18533 |
ZLDI-8 هو أحد مثبطات إنزيم ADAM-17 المنشط / المنشط للشق ويمنع انقسام بروتين Notchيقلل ZLDI-8 من التعبير عن البروتينات المؤيدة للبقاء / المضادة لموت الخلايا المبرمج والانتقال الظهاري المتوسط (EMT)ZLDI-8 هو أيضًا مثبط التيروزين فوسفاتيز التيروزين (Lyp) التنافسي وغير القابل للعكس مع IC50 من 31.6 ميكرومتر و Ki 26.22 ميكرومتريمنع ZLDI-8 نمو خلايا MHCC97-H مع IC من 5.32 ميكرومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 667880-38-8
Sample solution is provided at 25 µL, 10mM.
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ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM[1][2].
Reference:
[1]. Zhang Y, et al. Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells. Cell Death Dis. 2018 Jul 3;9(7):743.
[2]. Hou X, et al. Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening. J Med Chem. 2014 Nov 26;57(22):9309-22.
[1]. Zhang Y, et al. Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells. Cell Death Dis. 2018 Jul 3;9(7):743.
[2]. Hou X, et al. Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening. J Med Chem. 2014 Nov 26;57(22):9309-22.
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Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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