TAK-615 |
رقم الكتالوجGC61313 |
TAK-615 هو مُعدِّل خيفي سلبي (NAM) لمستقبل LPA1 لبحوث التليف الرئوي
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Cas No.: 1664335-55-0
Sample solution is provided at 25 µL, 10mM.
TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].
TAK-615 partially inhibits the LPA response (60% at 10 µM, IC50 of 91±30 nM)[1].
[1]. Jonathan Ellery, et al. Identification of Compounds Acting as Negative Allosteric Modulators of the LPA 1 Receptor. Eur J Pharmacol. 2018 Aug 15;833:8-15.
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