TAK-615 |
| Catalog No.GC61313 |
TAK-615 est un modulateur allostérique négatif (NAM) du récepteur LPA1 pour la recherche de la fibrose pulmonaire.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1664335-55-0
Sample solution is provided at 25 µL, 10mM.
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TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].
TAK-615 partially inhibits the LPA response (60% at 10 µM, IC50 of 91±30 nM)[1].
[1]. Jonathan Ellery, et al. Identification of Compounds Acting as Negative Allosteric Modulators of the LPA 1 Receptor. Eur J Pharmacol. 2018 Aug 15;833:8-15.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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