Colchicine-d6 |
| رقم الكتالوجGC47117 |
Colchicine-d6 هو الديوتيريوم المسمى كولشيسينالكولشيسين هو مثبط للتوبولين وعامل معطل للأنابيب الدقيقةالكولشيسين يمنع بلمرة الأنابيب الدقيقة باستخدام IC من 3 نانومتريعتبر الكولشيسين أيضًا مضادًا تنافسيًا لمستقبلات α3 الجلايسين (GlyRs)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1217651-73-4
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Colchicine-d6 is intended for use as an internal standard for the quantification of colchicine by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.1 It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM.1 Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.2,3
1.Martino, G.D., Regina, G.L., Coluccia, A., et al.Arylthioindoles, potent inhibitors of tubulin polymerizationJ. Med. Chem.47(25)6120-6123(2004) 2.McCarty, D.J.Urate crystals, inflammation, and colchicineArthritis Rheum.58(2)S20-S24(2008) 3.Chia, E.W., Grainger, R., and Harper, J.L.Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicineBr. J. Pharmacol.153(6)1288-1295(2008)
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *