Colchicine-d6 |
Catalog No.GC47117 |
La colchicine-d6 est le deutérium marqué Colchicine. La colchicine est un inhibiteur de la tubuline et un perturbateur des microtubules. La colchicine inhibe la polymérisation des microtubules avec une IC50 de 3 nM. La colchicine est également un antagoniste compétitif des récepteurs α3 de la glycine (GlyR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1217651-73-4
Sample solution is provided at 25 µL, 10mM.
Colchicine-d6 is intended for use as an internal standard for the quantification of colchicine by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.1 It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM.1 Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.2,3
1.Martino, G.D., Regina, G.L., Coluccia, A., et al.Arylthioindoles, potent inhibitors of tubulin polymerizationJ. Med. Chem.47(25)6120-6123(2004) 2.McCarty, D.J.Urate crystals, inflammation, and colchicineArthritis Rheum.58(2)S20-S24(2008) 3.Chia, E.W., Grainger, R., and Harper, J.L.Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicineBr. J. Pharmacol.153(6)1288-1295(2008)
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