Docetaxel (hydrate) (Synonyms: DTX, NSC 628503, RP 56976, Taxotel) |
| رقم الكتالوجGC48968 |
An analog of taxol with antitumor properties
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 700367-34-6
Sample solution is provided at 25 µL, 10mM.
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Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM).1 It has proven more effective than taxol in preventing the proliferation of cancer cells.1,2 Docetaxel has applications in breast cancer and hormone-
1.Bissery, M.C., Guenard, D., Gueritte-Voegelein, F., et al.Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogueCancer Research514845-4852(1991) 2.Pazdur, R., Kudelka, A.P., Kavanagh, J.J., et al.The taxoids: Paclitaxel (Taxolr) and docetaxel (Taxoterer)Cancer Treatment Reviews19351-386(1993) 3.Mahon, K.L., Henshall, S.M., Sutherland, R.L., et al.Pathways of chemotherapy resistance in castration-resistant prostate cancerEndocrine-Related Cancer18R103-R123(2011) 4.Yao, X., Hosenpud, J., Chitambar, C.R., et al.A phase II study of concurrent docetaxel, epirubicin and cyclophospha-mide as a neoadjuvant chemotherapy regimen in patients with locally advanced breast cancerJournal of Cancer3145-151(2012)
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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