Racecadotril-d5 (Synonyms: Acetorphan-d5) |
| رقم الكتالوجGC49108 |
An internal standard for the quantification of racecadotril
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1246815-11-1
Sample solution is provided at 25 µL, 10mM.
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Racecadotril-d5 is intended for use as an internal standard for the quantification of racecadotril by GC- or LC-MS. Racecadotril is a prodrug form of the neprilysin (NEP) inhibitor thiorphan .1,2 In vivo, racecadotril reduces or prevents castor oil-induced diarrhea without delaying intestinal transit in rats when administered at doses of 80 or 100 mg/kg, respectively.1 It also decreases the duration of diarrhea and increases body weight gain in a neonatal gnotobiotic pig model of human rotavirus-induced diarrhea.2 Formulations containing racecadotril have been used in the treatment of acute diarrhea.
1.Griggs, D.W., Prinsen, M.J., Oliva, J., et al.Pharmacologic comparison of clinical neutral endopeptidase inhibitors in a rat model of acute secretory diarrheaJ. Pharmacol. Exp. Ther.357(2)423-431(2016) 2.Bui, T., Li, G., Kim, I., et al.Effects of racecadotril on weight loss and diarrhea due to human rotavirus in neonatal gnotobiotic pigs (Sus scrofa domesticus)Comp. Med.67(2)157-164(2017)
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