Desethoxy Quetiapine (hydrochloride) (Synonyms: O-Desalkylquetiapine) |
| رقم الكتالوجGC49817 |
An active metabolite of quetiapine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 329218-14-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine .1 It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D2 receptors (IC50 = 1,330 nM).2,1 Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine receptor agonist apomorphine in mice. It also improves apomorphine-induced swimming deficits in mice.1
1.Warawa, E.J., Migler, B.M., Ohnmacht, C.J., et al.Behavioral approach to nondyskinetic dopamine antagonists: Identification of seroquelJ. Med. Chem.44(3)372-389(2001) 2.Bakken, G.V., Rudberg, I., Christensen, H., et al.Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5Drug Metab. Dispos.37(2)254-258(2009)
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *