Digoxigenin Bisdigitoxoside (Synonyms: Bisdigoxigenin) |
| رقم الكتالوجGC49842 |
A Na+/K+-ATPase inhibitor
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Cas No.: 5/2/5297
Sample solution is provided at 25 µL, 10mM.
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Digoxigenin bisdigitoxoside is a Na+/K+-ATPase inhibitor and an active cardiac glycoside metabolite of digoxin .1,2 It is formed from digoxin by the cytochrome P450 (CYP) isoform CYP3A.3 Digoxigenin bisdigitoxoside inhibits the Na+/K+-ATPase isoforms α1β1 and α2β1 with Ki values of 196 and 74 nM, respectively.
1.Katz, A., Tal, D.M., Heller, D., et al.Digoxin derivatives with enhanced selectivity for the α2 isoform of Na,K-ATPase: Effects on intraocular pressure in rabbitsJ. Biol. Chem.289(30)21153-21162(2014) 2.Abshagen, U., and Rietbrock, N.Metabolism of digoxigenin, digoxigeninmonodigitoxoside and digoxigeninbisdigitoxoside in ratsNaunyn Schmiedebergs Arch Pharmacol.276(2)157-166(1973) 3.Salphati, L., and Benet, L.Z.Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: Involvement of cytochrome P4503AXenobiotica29(2)171-185(1999)
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