Zoxazolamine (Synonyms: 2-Amino-5-chlorobenzoxazole, Contrazole, NSC 24995) |
| رقم الكتالوجGC13528 |
يستخدم Zoxazolamine على نطاق واسع للاختبار الدوائي الذي يعمل كمؤشر مناسب للتغيرات في نشاط السيتوكروم P-450 في القوارض
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Cas No.: 61-80-3
Sample solution is provided at 25 µL, 10mM.
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Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents.
Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. The time-averaged serum clearance determined from tested concentrations data is 7.22±1.01 mL/min/kg for Zoxazolamine. Infusion of Zoxazolamine to righting reflex (LRR) at three different rates shows increasing Zoxazolamine concentration in serum and brain at the onset of the effect with increasing infusion rates. When the Zoxazolamine infusion is continued for 5 min beyond the onset of LRR, the concentrations of Zoxazolamine in the cerebrospinal fluid (CSF) at the offset of LRR are essentially identical to the onset concentrations[1].
References:
[1]. Yasuhara M, et al. Pharmacodynamics of zoxazolamine and chlorzoxazone in rats. Pharm Res. 1988 Jul;5(7):401-7.
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