2-chloro Palmitic Acid (Synonyms: 2-ClHA, 2-CLPA) |
| رقم الكتالوجGC42135 |
2-chloro Palmitic Acid ، وهو وسيط شحمي التهابي ، يتداخل مع بروتين نخيل البروتين ، ويحفز علامات الإجهاد ER ، ويقلل من محتوى ER ATP ، وينشط نسخ وإفراز IL-6 وكذلك IL-8.2-chloro Palmitic Acid يعطل الميتوكوندريا إمكانات الغشاء ويحفز انشقاق procaspase-3 و PARP. 2-chloro Palmitic Acid يمكن أن يعبر حاجز الدم في الدماغ (BBB) ويقوض وظائف ER والميتوكوندريا في خط الخلايا البطانية للدماغ البشري hCMEC / D3.
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Cas No.: 19117-92-1
Sample solution is provided at 25 µL, 10mM.
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2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.
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