2-chloro Palmitic Acid (Synonyms: 2-ClHA, 2-CLPA) |
| Catalog No.GC42135 |
El Ácido 2-cloro palmÍtico, un mediador de lÍpidos inflamatorios, interfiere con la palmitoilaciÓn de proteÍnas, induce marcadores de estrés en el RE, reduce el contenido de ATP en el RE y activa la transcripciÓn y secreciÓn de IL-6, asÍ como IL-8.2-El Ácido cloro palmÍtico interrumpe la mitocondria potencial de membrana e induce la escisiÓn de procaspasa-3 y PARP. El Ácido 2-cloro palmÍtico puede atravesar la barrera hematoencefÁlica (BBB) y compromete las funciones ER y mitocondriales en la lÍnea de células endoteliales del cerebro humano hCMEC/D3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19117-92-1
Sample solution is provided at 25 µL, 10mM.
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2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.
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