bpV(phen) (potassium hydrate) (Synonyms: Bisperoxovanadium(phen), Potassium Bisperoxo(1,10phenanthroline) oxovanadate (V)) |
| رقم الكتالوجGC42969 |
bpV (فين) (هيدرات البوتاسيوم) ، عامل مقلد للأنسولين ، هو بروتين قوي التيروزين فوسفاتيز (PTP) ومثبط PTEN مع IC50s من 38 نانومتر ، 343 نانومتر و 920 نانومتر لـ PTEN ، PTP-β ؛ و PTP-1B على التوالي.
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Cas No.: 171202-16-7
Sample solution is provided at 25 µL, 10mM.
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bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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