C8 Ceramide (d18:1.8:0) (Synonyms: N-octanoyl-D-erythro-Sphingosine) |
| رقم الكتالوجGC43105 |
سيراميد C8 (d18:1.8:0) (N-Octanoyl-D-erythro-sphingosine) هو تشابه خلوي للسيراميدات الطبيعية الموجودة بالفعل والقابلة لاختراق الخلايا.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 74713-59-0
Sample solution is provided at 25 µL, 10mM.
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C8 Ceramide (d18:1.8:0) is a cell-permeable analog of naturally occurring ceramides. Unlike C2 ceramide, it is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels. [1] For this reason, treatment of cells with C8 ceramide (d18:1.8:0) may more closely mimic the effects of ceramide elevation than does treatment with shorter chain ceramide analogs. C8 Ceramide (d18:1.8:0) likely mediates many diverse biological activities, as do natural ceramides. It promotes the differentiation of human keratinocytes [2] and induces apoptosis of both human leukemia cells and the U937 cell line.[1] [3]
Reference:
[1]. Karasavvas, N., Erukulla, R.K., Bittman, R., et al. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. Eur. J. Biochem. 236(2), 729-737 (1996).
[2]. Wakita, H., Tokura, Y., Yagi, H., et al. Keratinocyte differentiation is induced by cell-permeant ceramides and its proliferation is promoted by sphingosine. Archives of Dermatological Research 286, 350-354 (1994).
[3]. Geley, S., Hartmann, B.L., and Kofler, R. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Letters 400, 15-18 (1997).
| Cas No. | 74713-59-0 | SDF | |
| المرادفات | N-octanoyl-D-erythro-Sphingosine | ||
| Chemical Name | N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide | ||
| Canonical SMILES | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCC)=O)CO | ||
| Formula | C26H51NO3 | M.Wt | 425.7 |
| الذوبان | 20mg/mL in DMSO, 22mg/mL in DMF, 33mg/mL in Ethanol | Storage | Store at -20℃, stored under nitrogen |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3491 mL | 11.7454 mL | 23.4907 mL |
| 5 mM | 0.4698 mL | 2.3491 mL | 4.6981 mL |
| 10 mM | 0.2349 mL | 1.1745 mL | 2.3491 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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