CCR1 antagonist 9 |
| رقم الكتالوجGC60678 |
مناهض CCR1 9 هو مناهض CCR1 قوي وانتقائي مع IC50of6.8 نانومتر في مقايسة تدفق الكالسيوم
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Cas No.: 1220026-26-5
Sample solution is provided at 25 µL, 10mM.
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CCR1 antagonist 9 is a potent and selective CCR1 antagonist with an IC50?of?6.8 nM in calcium flux assay[1].
CCR1 antagonist 9 (Compound 19e) blocks the CCR1 chemotaxis of THP-1 cells with an IC50 of 28 nM. CCR1 antagonist 9 also blocks hERG with an IC50 of 30 μM[1].
[1]. Harcken C, et al. Identification of novel azaindazole CCR1 antagonist clinical candidates. Bioorg Med Chem Lett. 2019 Feb 1;29(3):441-448.
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